Neutral Spheres

Pharmaceutical pellets, sometimes referred to as microparticulates, are free-flowing spherical particulates/beads ranging typically from 0.2–1.5 mm in size; however, other sizes are also frequently used. FDA Guidance for Industry sets the maximum limit of bead sizes that should not exceed 2.5–2.8 mm. The beads are used for manufacturing various multiple-unit pellet systems (MUPS), which are a kind of multiparticulate dosage form, where one or more drugs are split into numerous small independent subunits. As a drug product, MUPSs consist of drug-loaded pellets, which are either compressed into tablets or filled into hard capsules. In recent years, such multiparticulate dosage forms have gained considerable popularity, and more pharmaceutical preparations of such kind are increasingly present on the market.

Note* : DMF Available